Development of internal control methodology by using statistical methods of variability assessment of material flow business processes

Variability or instability is one of the key features of any process, including business processes of material flow internal control. Variability is a characteristic of all natural systems and technical processes. The objects which properties can be characterized via certain parameters arise at the output of any process. The article discloses the feasibility of using the statistical methods in the internal control system of business entities; in this case the focus is on the method of identifying the causes of variability using control charts of various types (Shewhart control charts) as a prime tool. The view points regarding variability of famous academic economists who researched the business process management issues are also considered. Authors’ classification of business process variation on types of material flow internal control with the allocation of controlled and uncontrolled variation is taken as the basis of the proposed application. The method of using control charts in estimating the efficiency of material flow internal control business processes is described in detail.peer-reviewe

Value-meaningful conceptualisation of educational material in the process of foreign language teaching at the university: A hermeneutic approach

Introduction. One of the main tasks of teaching foreign languages for professional purposes is the formation of professional communicative competence of students. In this regard, it is important for university teachers to create conditions for students to master the methods and techniques of productive communication, not only from the perspective of language and culture, but also their future profession. In addition to the logical and rational aspect, it is important for pedagogical students to focus on the value and semantic significance of educational information, to deeply understand rather than to memorise information, to be emotionally “engaged” into knowledge, filling it with personal meaning, in order to avoid formal mastering of pedagogical profession. This is possible in the context of the value and semantic conceptualisation of acquired knowledge, which is carried out in the process of interpreting and structuring the content of training by the principle of linguistic concept. Aim. The present research aims to substantiate the content, methods, techniques and forms of value meaningful conceptualisation of educational material in the process of teaching foreign languages to pedagogical students. Methodology and research methods are based on the study of the value-semantic foundations of pedagogical practice with reference to the cultural-historical concept; on the phenomenological-hermeneutical approach, aimed at the actualisation of the interpretive potential of the teaching content; on the utilisation of the methods of theoretical analysis and synthesis, deduction and induction, comparison, modelling, and methods of inclusive observation. The empirical study was conducted during one academic year (from September 2020 to June 2021) in the course “English for Specific Purposes (ESP)” with 60 students of Pedagogical Education major of the University of Tyumen. To assess the results of the experimental work the following tools were used: L. Michelson’s test, free associative experiment, the method of expert evaluation based on the level scale developed by the authors. Results. The obtained data confirmed the effectiveness of structuring learning content according to the linguistic concept image. In the course of the final test of communicative and professional skills, most students demonstrated a confident command of the basics of professional communication in English. Compared to the initial stage of the study, students’ professional communication in English became more productive. Students’ statements were distinguished by their meaningfulness, structure. They used additional material from other fields of knowledge, emotional and value coloring in the form of metaphors, idioms, statements of famous teachers, precedent texts, the ability to improvise, etc. Scientific novelty. The authors didactically proved the productivity of the hermeneutic approach in the design of teaching foreign languages on the basis of structuring teaching material by the principle of linguistic concept, which is a mediating link between the scientific concept, on the one hand, and the individual consciousness and the subjective personal experience of students, on the other hand. Practical significance. The results of this study can be used by teachers in order to achieve a balance between technological and axiological aspects of learning and cognitive activities of students for mastering their pedagogical knowledge, professional and personal experience, which will ultimately contribute to the enhancement of professional training of future educators.Введение. Одной из основных задач преподавания иностранных языков для профессиональных целей является формирование профессиональной коммуникативной компетенции студентов. В этой связи в процессе обучения преподавателям вуза важно создать условия для освоения студентами способов и приемов осуществления продуктивного общения не только с позиции языка и культуры, но и их будущей профессии. Во избежание формального освоения педагогической профессии студентам педагогических специальностей важно, помимо логико-гносеологического аспекта, ориентироваться на ценностно-смысловую значимость учебной информации, глубоко понимать, а не запоминать, эмоционально «проживать» знание, наполняя его личностными смыслами. Это возможно в условиях ценностно-смысловой концептуализации осваиваемого знания, осуществляемой в процессе интерпретации и структурирования содержания обучения по образу лингвоконцепта. Цель – обоснование содержания, методов, приемов и форм ценностно-смысловой концептуализации учебного материала в процессе обучения иностранным языкам студентов педагогических специальностей. Методология, методы и методика. В основу работы положены исследование ценностно-смысловых оснований педагогической деятельности с обращением к культурно-исторической концепции, а также феноменолого-герменевтический подход, направленный на актуализацию интерпретационного потенциала содержания обучения. Использованы методы теоретического анализа и синтеза, дедукции и индукции, сравнения, моделирования, включённого наблюдения. Эмпирическое исследование проводилось в течение одного академического года (с сентября 2020 года по июнь 2021 года) на занятиях по «Иностранному языку в профессиональной сфере (английский язык)» с участием 60 студентов, обучающихся на направлении «Педагогическое образование» Тюменского государственного университета. Для оценки результатов опытной работы использовались: тест Л. Михельсона, свободный ассоциативный эксперимент, метод экспертной оценки на основе разработанной авторами уровневой шкалы. Результаты. Полученные в результате исследования данные подтвердили эффективность структурирования содержания обучения по образу лингвоконцепта. В ходе итогового тестирования коммуникативных и профессиональных умений и навыков большинство студентов продемонстрировали уверенное владение основами профессиональной коммуникации на английском языке. По сравнению с начальным этапом исследования профессиональная коммуникация студентов на английском языке стала более продуктивной. Высказывания отличались осмысленностью, структурированностью, привлечением дополнительного материала из других областей знания, эмоционально-ценностной окрашенностью в виде метафор, идиом, высказываний известных педагогов, прецедентных текстов, умением осуществлять импровизацию и др. Научная новизна. Дидактически обоснована продуктивность герменевтического подхода в проектировании обучения иностранным языкам на основе структурирования учебного материала по принципу лингвоконцепта, который является опосредующим звеном между научным понятием, с одной стороны, и индивидуальным сознанием и субъективно-личностным опытом обучающихся, с другой.Авторы выражают благодарность рецензентам за экспертное мнение и конструктивный подход.The authors express their gratitude to the reviewers for their expert opinion and constructive approach

Туберкулез у детей и подростков последнего десятилетия

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Локальный туберкулез у детей раннего возраста

The purpose is to study clinical and X-ray manifestations of local tuberculosis in children of the tender age and to detect risk factors promoting the development of the disease and complicating it, thus the analysis included 82 cases of children cases under 3 years old who had been treated in Children TB Hospital in 2013-2015. Tuberculosis of chest lymph nodes was diagnosed in 68.3%of them, and every fifth child had primary tuberculosis complex. Every other child was suffering from the complicated course of local tuberculosis (n = 42). The following forms were registered: bronchial pulmonary lesions (n = 27), lymphogenic progression (n = 13), including development of disseminated tuberculosis and meningitis. Positive results of sputum tests were observed in 14 (17.1%) children, of them 50% had multiple drug resistance. 10% of children suffering from tuberculosis manifested anergy. The predictors of such course of the disease included the absence of BCG vaccination and super infection with Mycobacterium tuberculosis.С целью изучения клинико-рентгенологических проявлений локального туберкулеза у детей раннего возраста и выявления факторов риска, способствующих развитию заболевания и отягощающих течение туберкулезного процесса, проведен анализ 82 историй болезни детей в возрасте до 3 лет, лечившихся в Детской туберкулезной больнице в 2013-2015 гг. Туберкулез внутригрудных лимфатических узлов диагностировали у 68,3%, первичный туберкулезный комплекс - у каждого пятого. Осложненное течение локальных форм - у каждого второго (n = 42). Регистрировались: бронхолегочные поражения (n = 27), лимфогематогенное прогрессирование (n = 13), в том числе с развитием диссеминированного туберкулеза, менингита. Бактериовыделение - у 14 (17,1%) детей, из них с множественной лекарственной устойчивостью возбудителя - у 50,0%. Туберкулез у 10% детей протекал на фоне анергии. К предикторам такого течения отнесены отсутствие прививки БЦЖ, суперинфекция МБТ

Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry

Aims: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50\u20133.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78\u20131.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting. Conclusion: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621

Contrasting Patterns of Transposable Element Insertions in Drosophila Heat-Shock Promoters

The proximal promoter regions of heat-shock genes harbor a remarkable number of P transposable element (TE) insertions relative to both positive and negative control proximal promoter regions in natural populations of Drosophila melanogaster. We have screened the sequenced genomes of 12 species of Drosophila to test whether this pattern is unique to these populations. In the 12 species' genomes, transposable element insertions are no more abundant in promoter regions of single-copy heat-shock genes than in promoters with similar or dissimilar architecture. Also, insertions appear randomly distributed across the promoter region, whereas insertions clustered near the transcription start site in promoters of single-copy heat-shock genes in D. melanogaster natural populations. Hsp70 promoters exhibit more TE insertions per promoter than all other genesets in the 12 species, similarly to in natural populations of D. melanogaster. Insertions in the Hsp70 promoter region, however, cluster away from the transcription start site in the 12 species, but near it in natural populations of D. melanogaster. These results suggest that D. melanogaster heat-shock promoters are unique in terms of their interaction with transposable elements, and confirm that Hsp70 promoters are distinctive in TE insertions across Drosophila

Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights regarding neurological disease entities triggering TTS and to investigate the clinical profile and outcomes of TTS patients after primary neurological disorders. The International Takotsubo Registry is an observational multicenter collaborative effort of 45 centers in 14 countries (ClinicalTrials.gov, identifier NCT01947621). All patients in the registry fulfilled International Takotsubo Diagnostic Criteria. For the present study, patients were included if complete information on acute neurological disorders were available. 2402 patients in whom complete information on acute neurological status were available were analyzed. In 161 patients (6.7%) an acute neurological disorder was identified as the preceding triggering factor. The most common neurological disorders were seizures, intracranial hemorrhage, and ischemic stroke. Time from neurological symptoms to TTS diagnosis was ≤ 2 days in 87.3% of cases. TTS patients with neurological disorders were younger, had a lower female predominance, fewer cardiac symptoms, lower left ventricular ejection fraction, and higher levels of cardiac biomarkers. TTS patients with neurological disorders had a 3.2-fold increased odds of in-hospital mortality compared to TTS patients without neurological disorders. In this large-scale study, 1 out of 15 TTS patients had an acute neurological condition as the underlying triggering factor. Our data emphasize that a wide spectrum of neurological diseases ranging from benign to life-threatening encompass TTS. The high rates of adverse events highlight the need for clinical awareness.The International Takotsubo Registry was supported by the Biss Davies Charitable Trust. Dr. Scheitz has been supported by the Corona Foundation. Dr. Templin has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation.info:eu-repo/semantics/publishedVersio

Prognostic impact of acute pulmonary triggers in patients with Takotsubo syndrome : new insights from the International Takotsubo Registry

© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33-3.38; P = 0.002). Conclusions: The present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome.C. T. has been supported by the H.H. Sheikh Khalifa binHamad Al-Thani Research Programme and the Swiss HeartFoundation. The InterTAK Registry is supported by the BissDavies Charitable Trust. L. S. M. has been supported by EUHORIZON 2020(SILICOFCM ID777204)info:eu-repo/semantics/publishedVersio

The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review

<p>Abstract</p> <p>Background</p> <p>In 2004, tuberculosis (TB) was responsible for 2.5% of global mortality (among men 3.1%; among women 1.8%) and 2.2% of global burden of disease (men 2.7%; women 1.7%). The present work portrays accumulated evidence on the association between alcohol consumption and TB with the aim to clarify the nature of the relationship.</p> <p>Methods</p> <p>A systematic review of existing scientific data on the association between alcohol consumption and TB, and on studies relevant for clarification of causality was undertaken.</p> <p>Results</p> <p>There is a strong association between heavy alcohol use/alcohol use disorders (AUD) and TB. A meta-analysis on the risk of TB for these factors yielded a pooled relative risk of 2.94 (95% CI: 1.89-4.59). Numerous studies show pathogenic impact of alcohol on the immune system causing susceptibility to TB among heavy drinkers. In addition, there are potential social pathways linking AUD and TB. Heavy alcohol use strongly influences both the incidence and the outcome of the disease and was found to be linked to altered pharmacokinetics of medicines used in treatment of TB, social marginalization and drift, higher rate of re-infection, higher rate of treatment defaults and development of drug-resistant forms of TB. Based on the available data, about 10% of the TB cases globally were estimated to be attributable to alcohol.</p> <p>Conclusion</p> <p>The epidemiological and other evidence presented indicates that heavy alcohol use/AUD constitute a risk factor for incidence and re-infection of TB. Consequences for prevention and clinical interventions are discussed.</p

Ethnic comparison in takotsubo syndrome : novel insights from the International Takotsubo Registry

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Background: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients. Results: A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 ± 11.4 years vs. 68.0 ± 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p < 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p < 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients. Conclusion: Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers.Open Access funding provided by Universität Zürich. CT has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation. L.S.M. has been supported by EU HORIZON 2020 (SILICOFCM ID777204). J.R.G has received a grant “Filling the gap” from the University of Zurich. The InterTAK Registry is supported by The Biss Davies Charitable Trust.info:eu-repo/semantics/publishedVersio